Although there doesn't seem to yet be definitive answers to this question. There are quite a few hypothesis out there, all which sound pretty legit to me. The most basic one, is that alcohol contains a lot of sugar. And usually, before we know we're going on a big binge, we tend to stock up on carbs, to 'absorb' the alcohol. That means that we're consuming high quantities of sugar and once our body digests that and breaks it all down, our blood sugar eventually drops, leaving us hungry. Now, this is the most basic idea that I read. The other one gets much more complicated and scientific but I'll try to simplify it as best as I can.
In conjunction with the theory that eating so many foods with sugar in them, and thereby temporarily raising our blood sugar, the body must prepare for this rise in blood sugar by increasing the production of insulin. This spike in insulin production interferes with the function of leptin, a protein hormone that affects our appetite. Leptin is involved with regulating how the body takes in and expends energy, which we get from food. Low levels of leptin, or preventing leptin from properly interacting with the brain, increases appetite.
Ghrelin is another hormone that also affects our appetites. It is a hormone found mostly in the stomach but can also be found in the hypothalamic region. There is an increase in ghrelin before we eat, and a reduction of it after our meal. When ghrelin is activated it increases our appetites and fat mass; it is sensitive to leptin as well as insulin levels.
And finally, when we drink, our brain releases an amino acid peptide neurotransmitter, called neuropeptide Y (NPY). NPY is secreted by the hypothalamus and tends to increase our desire for food intake as well as affecting the way energy is stored as fat. Fat now tends to be stored more in the abdominal area (not sexy on men or women, just an fyi). NPY also works together with ghrelin and leptin in your body to contribute to hunger when you've been drinking, I just can't totally figure it all out from all the scientific talk, but I know that it says it somewhere.
All three of these work together to make us hungrier when we've been drinking, and needless to say, when we've been drinking it's harder for us to resist what our bodies want. Now that I know it is biological, I won't feel so bad having that last slice at the end of the night, cause if it tastes so good, how can it be wrong?

